Book Title: Immunotoxin Methods and Protocols
Author(s): Walter A. Hall
Category: Medical Science
Series: Methods in Molecular Biology
Publisher: Humana Press, Year: 2001
Immunotoxin Methods and Protocols
Hands-on experts from laboratories around the world describe in step-by-step detail their cutting-edge methods for developing and applying these powerful proteins. The conjugates created by these researchers contain entire monoclonal antibodies, single-chain antibody fragments, and cytokines as their carrier ligands. Their toxic portion can include such conventional chemotherapeutics as doxorubicin, such ribosome-inactivating proteins the ricin A chain or saporin, or such bacterial toxins as diphtheria toxin. Also described are a variety of applications that demonstrate the versatility of these agents, including the treatment of primary malignant brain tumors, the generation of selective brain lesions to localize critical functions, and the targeting of the AIDS virus. Authoritative and highly practical, Immunotoxin Methods and Protocols provides today’s cancer researchers, neuroscientists, and oncologists with state-of-the-art tools for exploring these powerful biological agents and their rapidly increasing applications.